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Fang Watch
1 Oct 2010
Open Letter in Support of
Chuan-Guo Xiao, M.D. from the
International Academic Community
September
29, 2010
(sci.rutgers.edu/forum/attachment.php?attachmentid=37089&d=1285820875)
To
all,
We
have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years. He is an
internationally respected
surgeon-scientist who has made major
advances in the development of
neuroregeneration to restore voiding and
bowel function. Dr. Xiao performed
groundbreaking animal research in the
United States, demonstrating that a
motor nerve that innervates the leg can
be used to reinnervate the bladder and
bowel. This reinnervation allows for
development of a reflex to initiate
bladder function. The results of his
studies were published in peer-reviewed
journals and other scientists have
replicated Xiao’s findings confirming
these results.
Dr.
Xiao eventually took the courageous step
of moving from animal research to human
studies and began performing the
rerouting procedure on patients with
spinal cord injury and spina bifida in
China. Neurogenic bladder is life
threatening in China due to a lack of
both antimuscarinics and intermittent
catheterization, and lessening the
complications of neurogenic bladder would
be considered a lifesaving success.
Patients with neurogenic bladder and
bowel suffer greatly and endure a host of
issues such as urinary retention,
incontinence, recurrent infections, renal
insufficiency,fecal incontinence,
constipation, and poor quality of life.
For a procedure as complicated as nerve
rerouting requiring nerve regeneration,
one cannot expect normalization of
bladder and bowel function to be the
definition of success. What is important
is that the benefits outweigh the risks
of the procedure.
Dr.
Xiao published his clinical results in
peer-reviewed journals and was twice
honored by the Jack Lapides Essay
Contest, one of the most respected
international awards given to scientists
who make major contributions to the field
of neurourology.In 2008, he was named the
Kelm Hjalmas Memorial Lecturer from the
International Children’s Continence
Society for his scientific achievements.
Many of us have traveled to China to
examine patients treated by Dr. Xiao
and/or have been trained by him in the
nerve rerouting surgery he invented. Dr. Xiao is a very skilled
surgeon who is passionate about patient
care and
works tirelessly to train physicians
around the world in performing his nerve
rerouting procedure.
In
the United States, an independent and
very rigorous pilot research trial was
performed to test the safety and efficacy
of this procedure. The one-year results
were recently published in the Journal of
Urology. At the 12-month follow-up visit,
a cutaneous to bladder reflex was found
in 7 of 9 spina bifida patients,
confirming that rerouting does occur.
This finding by itself is remarkable and
Dr. Xiao should be commended. In
addition, a number of patients
demonstrated improvement in bladder and
bowel function, which has continued to
improve with longer patient follow-up.
The 36-month results are currently being
analyzed and will be reported in the near
future. The pilot data was supportive of
Dr. Xiao’s procedure, and now an NIH
sponsored clinical trial is being
conducted to further study lumbar to
sacral nerve rerouting in spina bifida
patients. In addition, similar procedures
have been done worldwide, with Dr. Xiao
helping to mentor the surgeons at each
site.
The
Chinese people and government should be
proud of Dr. Xiao for his dedication to
his patients, his scientific
achievements, and his willingness to
train doctors around the world how to
perform his surgery. The International
scientific community was shocked to hear
of Dr. Xiao’s arrest. Those of us who know Dr.
Xiao well find it difficult to believe
that he is involved in these attacks. Dr.
Xiao is a compassionate man who is
respected worldwide for his integrity and
his innovative scientific contributions
to society. We implore the Chinese
government and authorities to treat Dr.
Xiao fairly and to protect his human
rights as these charges are investigated.
Please strongly consider Dr. Xiao’s
scientific and humanitarian contributions
to the world as facts are gathered in
this case.
Sincerely,
Kenneth M. Peters,
MD
Professor and Chairman of Urology
Beaumont Hospital
Royal Oak, Michigan USA
Jack S. Elder,
M.D.
Chief of Urology, Henry Ford Health
System
Associate Director, Vattikuti Urology
Institute
Department of Urology,
Children\\'s Hospital of Michigan
Detroit, MI USA
Edwin A. Smith
M.D.
Assistant Clinical Professor of Urology
Emory University School of Medicine
Atlanta, Georgia USA
Kevin M. Feber,
MD, FAAP
Beaumont Children\\'s Hospital
Royal Oak, MI USA
Ananias C. Diokno,
M.D., F.A.C.S.
Executive Vice President & CMO
Beaumont Hospital
Royal Oak, Michigan 48073 USA
Juan José de
Benito
Urologist
Hospital Nacional de Clínicas
Córdoba, Argentina.
William E. Nantau
B.Sc., CNIM
Clinical Manager
Clinical Neurophysiology Department
Beaumont Hospital Royal Oak, MI USA
Evan J Kass
MD,FACS,FAAP
Chief, Division of Pediatric Urology
Beaumont Childrens Hospital
Professor of Urology, Oakland
University-William
Beaumont School of Medicine USA
Jacques Corcos MD.
Professor of Urology, McGill University
General Secretary of the International
Continence
Society
Jewish General hospital
3755 Cote Ste-Catherine
Montreal, Quebec, Canada H3T 1E2
Jose Gonzalez,
M.D.
Department of Urology
Beaumont Hospital
Royal Oak, Michigan USA
Christopher Payne,
MD
Associate Professor of Urology
Stanford University Medical School
Stanford, CA 94305-5118 USA
Kenneth I.
Glassberg, MD
Director, Division of Pediatric Urology
Morgan Stanley Children\\'s Hospital of
New York-
Presbyterian
Professor of Urology, Columbia University
College of Physicians and Surgeons
3959 Broadway, CHN 1118 NY USA
Earl Y. Cheng, MD
Associate Professor of Urology
Children’s Memorial Hospital
Chicago, Illinois USA
Darius J. Bagli,
MDCM
Professor of Surgery
Senior Associate Scientist
Director of Urology Research
Divisions of Urology and
Developmental & Stem Cell Biology
The Hospital For Sick Children
Institute of Medical Science
University of Toronto
Henri B. LOTTMANN,
MD, FEBU, FEBPS,
FRCS(england) FEBPU
Paediatric urology unit
Hopital Necker-Enfants-Malades
149, rue de Sèvres
75015 Paris, France
Dr. Amrish Vaidya
MS. MCh.
Consultant Paediatric Surgeon,
Kokilaben Dhirubhai Ambani Hospital,
4 Bungalows, Andheri W, Mumbai, India
Marc Cendron, MD
Associate Professor in Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA USA
Stuart B. Bauer,
MD
Associate Director, Neurourology
Professor of Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA USA
Edmond T.
Gonzales, Jr., MD
Professor of Urology
Baylor College of Medicine
Houston TX USA
Richard Macchia, MD FACS
SUNY Distinguished Teaching Professor
Cleveland Clinic, Florida
Benjamin Girdler,
MD
Urology Center of the Rockies
Fort Collins, Colorado USA
William C. de
Groat, Ph.D.
Professor of Pharmacology
University of Pittsburgh
Pittsburgh, PA USA
Michael R.
Ruggieri, Sr., Ph.D.
Director of Urologic Research
Temple University School of Medicine
Philadelphia, PA USA
Stanley J Kogan MD
Chief, Pediatric Urology
Children\\'s Hospital at Montefiore
Bronx NY USA
Anthony Caldamone,
MD
University Urologic Associates, Inc.
2 Dudley St Ste 185
Providence, RI 02905 USA
Yves Homsy MD,
FRCSC, FAAP
Clinical Professor of Urological Surgery
and
Pediatrics
University of South Florida
Children\\'s Urology Group
5507 E. Longboat Blvd
Tampa FL 33615 USA
Dr. Enrique Turina
Professor of urology of the National
University of
Buenos Aires
Chief of section Urology of Instituto de
Rehabilitación
Government of Buenos Aires, Argentina.
Dr. Angel Ozón
Urologist of the Instituto de
Rehabilitación of Buenos
Aires
Dr. Daniel Ekizian
Urologist of Instituto de
Rehabilitación.
Professor Dr. med. Karl-Dietrich Sievert
Vice Chair
Prof. of Urology, Director -
Uro-oncology,
Neurourology, Incontinence, &
Reconstructive
Urology
Department of Urology University of
Tuebingen
D72076 Tuebingen, Germany
Holly Gilmer, MD
Chief of Pediatric Neurosurgery
Beaumont Hospital
Royal Oak, Michigan USA
Yegappan
Lakshmanan, MD
Chief, Pediatric Urology
Children’s Hospital of Michigan
Detroit, MI USA
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